Blockade of LAG-3 in PD-L1-Deficient Mice Enhances Clearance of Blood Stage Malaria Independent of Humoral Responses

Blockade of LAG-3 in PD-L1-Deficient Mice Enhances Clearance of Blood Stage Malaria Independent of Humoral Responses

T cells expressing high levels of inhibitory receptors such as PD-1 and LAG-3 are a hallmark of chronic infections and cancer. Checkpoint blockade therapies targeting these receptors have been largely validated as promising strategies to restore exhausted T cell functions and clearance of chronic in...

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Bibliographic Details
Main Authors: Raquel Furtado, Laurent Chorro, Natalie Zimmerman, Erik Guillen, Emily Spaulding, Shu Shien Chin, Johanna P. Daily, Grégoire Lauvau
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
checkpoint therapeutic blockade
PD-1/PD-L1/LAG-3
inhibitory receptors
malaria
humoral immunity
LAG-3+ CD4+ and CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.576743/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.576743/full

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