Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor.

The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains including the LXCXE or RB-binding motif, the DNA bindi...

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Main Authors: Debrah A Fine, Orit Rozenblatt-Rosen, Megha Padi, Anna Korkhin, Robert L James, Guillaume Adelmant, Rosa Yoon, Luxuan Guo, Christian Berrios, Ying Zhang, Michael A Calderwood, Soundarapandian Velmurgan, Jingwei Cheng, Jarrod A Marto, David E Hill, Michael E Cusick, Marc Vidal, Laurence Florens, Michael P Washburn, Larisa Litovchick, James A DeCaprio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093934/?tool=EBI