Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2

Endothelial AIP1 Regulates Vascular Remodeling by Suppressing NADPH Oxidase-2

Objective: AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. However, the direct role of AIP1 in endothelium, vascular remodeling and associated vascular diseases has not been determined.Approach...

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Bibliographic Details
Main Authors: Jiqin Zhang, Chaofei Chen, Li Li, Huanjiao J. Zhou, Fenghe Li, Haifeng Zhang, Luyang Yu, Yuxin Chen, Wang Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
AIP1
NOX2
reactive oxygen species
vascular remodeling
neointimal hyperplasia
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00396/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00396/full

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