Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy

Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy

Mitochondrial dysfunction is related to the pathogenesis of osteoarthritis (OA); however, there are no effective drugs to treat OA for maintaining mitochondrial homeostasis. Studies have shown that mitochonic acid-5 (MA-5) has a protective effect against mitochondrial damage and plays a role in mito...

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Bibliographic Details
Main Authors: Ruobing Xin, Yiyang Xu, Dianbo Long, Guping Mao, Hongyi Liao, Ziji Zhang, Yan Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
mitochondrial dysfunction
mitochondrial homeostasis
mitophagy
osteoarthritis
pathogenesis
MA-5
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.911716/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.911716/full

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