Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma

Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma

Abstract Background Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HCC). Methods Two hundred twenty-three surgically resected HCCs were subj...

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Bibliographic Details
Main Authors: Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Multiple mutations
Hypermutation
MUC16
Online Access:https://doi.org/10.1186/s12885-022-10143-z

Internet

https://doi.org/10.1186/s12885-022-10143-z

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