HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML

HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML

Abstract Background: Leukaemia stem cells (LSCs) are responsible for the initiation, maintenance, and recurrence of acute myeloid leukaemia (AML), an aggressive haematological malignancy associated with drug resistance and relapse. Identifying therapeutic LSC targets is critical to curing AML. Metho...

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Bibliographic Details
Main Authors: Zheng Li, Fangce Wang, Xiaoxue Tian, Jun Long, Bin Ling, Wenjun Zhang, Jun Xu, Aibin Liang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Acute myeloid leukaemia (AML)
Haematopoietic cell kinase (HCK)
Leukaemia stem cells (LSCs)
Self-renewal
Cell cycle
Cyclin-dependent kinase 6 (CDK6).
Online Access:https://doi.org/10.1186/s13046-021-02007-4

Internet

https://doi.org/10.1186/s13046-021-02007-4

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