Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies

Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies

New-generation catheters-based renal denervation (RDN) is under investigation for the treatment of uncontrolled hypertension (HTN). We assessed the feasibility of a large animal model of HTN to accommodate the human RDN devices. Ten minipigs were instrumented to measure blood pressure (BP) in an awa...

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Bibliographic Details
Main Authors: Armando Pérez de Prado, Claudia Pérez-Martínez, Marta Regueiro-Purriños, Carlos Cuellas-Ramón, María López-Benito, José Manuel Gonzalo-Orden, Rodrigo Estévez-Loureiro, Ana Isabel Cortina-Rivero, David Viñuela-Baragaño, José R Altonaga, Armando Tellez, Felipe Fernández-Vázquez
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Animals
Subjects:
hypertension
DOCA
renal denervation
radiofrequency
swine
histology
Online Access:https://www.mdpi.com/2076-2615/10/9/1446

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https://www.mdpi.com/2076-2615/10/9/1446

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