Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-Genetic Heterogeneity in Prostate Cancer Cells

Coupled Feedback Loops Involving PAGE4, EMT and Notch Signaling Can Give Rise to Non-Genetic Heterogeneity in Prostate Cancer Cells

Non-genetic heterogeneity is emerging as a crucial factor underlying therapy resistance in multiple cancers. However, the design principles of regulatory networks underlying non-genetic heterogeneity in cancer remain poorly understood. Here, we investigate the coupled dynamics of feedback loops invo...

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Bibliographic Details
Main Authors: Divyoj Singh, Federico Bocci, Prakash Kulkarni, Mohit Kumar Jolly
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Entropy
Subjects:
non-genetic heterogeneity
multistability
oscillations
prostate cancer
feedback loops
PAGE4
Online Access:https://www.mdpi.com/1099-4300/23/3/288

Internet

https://www.mdpi.com/1099-4300/23/3/288

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