Rev-erbs and Glia—Implications for Neurodegenerative Diseases
Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist diminished the severity of lipopolysaccharide (LPS)-i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-06-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519853233 |
| _version_ | 1818339755982585856 |
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| author | Percy Griffin Julie M Dimitry Erik S Musiek |
| author_facet | Percy Griffin Julie M Dimitry Erik S Musiek |
| author_sort | Percy Griffin |
| collection | DOAJ |
| description | Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist diminished the severity of lipopolysaccharide (LPS)-induced neuroinflammation. Concomitant with this glial activation is impaired neuronal health. These findings suggest that Rev-erb proteins may play critical roles in glial biology. Pertinent ideas such as the glial cell type of most importance, the translatability of these findings to human disease, and the effect of manipulating Rev-erbs in models of neurodegeneration, need to be explored further. In this commentary, we will address the potential role of Rev-erbs in neuroinflammation related to neurodegenerative diseases and speculate on Rev-erbs as potential therapeutic targets for these conditions. |
| first_indexed | 2024-12-13T15:32:03Z |
| format | Article |
| id | doaj.art-a9f53dc35f174555b9c6652e9a945781 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-12-13T15:32:03Z |
| publishDate | 2019-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-a9f53dc35f174555b9c6652e9a9457812022-12-21T23:40:08ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952019-06-011310.1177/1179069519853233Rev-erbs and Glia—Implications for Neurodegenerative DiseasesPercy GriffinJulie M DimitryErik S MusiekRecently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist diminished the severity of lipopolysaccharide (LPS)-induced neuroinflammation. Concomitant with this glial activation is impaired neuronal health. These findings suggest that Rev-erb proteins may play critical roles in glial biology. Pertinent ideas such as the glial cell type of most importance, the translatability of these findings to human disease, and the effect of manipulating Rev-erbs in models of neurodegeneration, need to be explored further. In this commentary, we will address the potential role of Rev-erbs in neuroinflammation related to neurodegenerative diseases and speculate on Rev-erbs as potential therapeutic targets for these conditions.https://doi.org/10.1177/1179069519853233 |
| spellingShingle | Percy Griffin Julie M Dimitry Erik S Musiek Rev-erbs and Glia—Implications for Neurodegenerative Diseases Journal of Experimental Neuroscience |
| title | Rev-erbs and Glia—Implications for Neurodegenerative Diseases |
| title_full | Rev-erbs and Glia—Implications for Neurodegenerative Diseases |
| title_fullStr | Rev-erbs and Glia—Implications for Neurodegenerative Diseases |
| title_full_unstemmed | Rev-erbs and Glia—Implications for Neurodegenerative Diseases |
| title_short | Rev-erbs and Glia—Implications for Neurodegenerative Diseases |
| title_sort | rev erbs and glia implications for neurodegenerative diseases |
| url | https://doi.org/10.1177/1179069519853233 |
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