Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

L-Azetidine-2-carboxylic acid (AZE) is a toxic non-protein coding amino acid (npAA) that is highly abundant in sugar and table beets. Due to its structural similarity with the amino acid L-proline, AZE can evade the editing process during protein assembly in eukaryotic cells and be misincorporated i...

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Bibliographic Details
Main Authors: Jordan Allan Piper, Margo Iris Jansen, Sarah Thomas Broome, Kenneth J. Rodgers, Giuseppe Musumeci, Alessandro Castorina
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Current Issues in Molecular Biology
Subjects:
L-azetidine-2-carboxylic acid
microglia
beets
multiple sclerosis
non-protein amino acid
neuroinflammation
Online Access:https://www.mdpi.com/1467-3045/44/10/308

Internet

https://www.mdpi.com/1467-3045/44/10/308

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