Two types of human TCR differentially regulate reactivity to self and non-self antigens

Two types of human TCR differentially regulate reactivity to self and non-self antigens

Summary: Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is regulated by variations in thymic output and terminal deoxynucleotidyl transferase (TDT) activity....

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Bibliographic Details
Main Authors: Assya Trofimov, Philippe Brouillard, Jean-David Larouche, Jonathan Séguin, Jean-Philippe Laverdure, Ann Brasey, Gregory Ehx, Denis-Claude Roy, Lambert Busque, Silvy Lachance, Sébastien Lemieux, Claude Perreault
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Immune response
Immunity
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222012408

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http://www.sciencedirect.com/science/article/pii/S2589004222012408

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