Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion

Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion

BackgroundCardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone dea...

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Bibliographic Details
Main Authors: Joseph B. Moore, John Zhao, Annalara G. Fischer, Matthew C.L. Keith, David Hagan, Marcin Wysoczynski, Roberto Bolli
Format: Article
Language:English
Published: Wiley 2017-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac mesenchymal stromal cells
histone deacetylase inhibitors
histone deacetylases
paracrine signaling
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006183

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https://www.ahajournals.org/doi/10.1161/JAHA.117.006183

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