Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43

Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43

Abstract Background Astrocyte Connexin 43 (Cx43) is essential for the trophic and protective support of neurons during brain ischemia reperfusion (I/R) injury. It is believed that dexmedetomidine participates in Cx43-mediated effects. However, its mechanisms remained unclear. This study aims to addr...

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Bibliographic Details
Main Authors: Xiaoyang Zheng, Xiaoying Cai, Fang Ye, Ying Li, Qin Wang, Zhiyi Zuo, Wenqi Huang, Zhongxing Wang
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Anesthesiology
Subjects:
Brain ischemia
Reperfusion injury
Dexmedetomidine
Astrocytes
Connexin 43
Online Access:https://doi.org/10.1186/s12871-020-01211-7

Internet

https://doi.org/10.1186/s12871-020-01211-7

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