Phylodynamic analysis of the emergence and epidemiological impact of transmissible defective dengue viruses.

Intra-host sequence data from RNA viruses have revealed the ubiquity of defective viruses in natural viral populations, sometimes at surprisingly high frequency. Although defective viruses have long been known to laboratory virologists, their relevance in clinical and epidemiological settings has no...

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Bibliographic Details
Main Authors: Ruian Ke, John Aaskov, Edward C Holmes, James O Lloyd-Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3585136?pdf=render