Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy

Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy

Long-term antiretroviral therapy (ART) in people living with HIV (PLHIV) is associated with sustained increases in CD4+ T-cell count, but its effect on the peripheral blood T-cell repertoire has not been comprehensively evaluated. In this study, we performed serial profiling of the composition and d...

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Bibliographic Details
Main Authors: Andrea M. H. Towlerton, Shashidhar Ravishankar, David G. Coffey, Camille E. Puronen, Edus H. Warren
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
HIV
T-cell repertoire analysis
Antiretroviral therapy (ART)
Immune restoration
TCR sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.879190/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.879190/full

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