Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal slice preparations in the stratum lacunosum molecul...

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Bibliographic Details
Main Authors: Michael Spedding, Claude Sebban, Thérèse M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szénási, György I. Lévay, Katalin Megyeri, Jozsef Barkóczy, Laszlo G. Hársing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsályi
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
schizophrenia
EGIS 11150
S 36549
theta rhythm
phencyclidine
ketamine
Online Access:https://www.mdpi.com/2073-4409/11/7/1181

Internet

https://www.mdpi.com/2073-4409/11/7/1181

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