Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer

Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer

Background CD8+tumor infiltrating lymphocytes (TILs) are often observed in non-small cell lung cancers (NSCLC). However, the characteristics of CD8+ TILs, especially T-cell populations specific for tumor antigens, remain poorly understood.Methods High throughput single-cell RNA sequencing and single...

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Bibliographic Details
Main Authors: Hiroyuki Kishi, Hirokazu Matsushita, Hiroshi Hamana, Yuki Tanaka, Yusuke Takahashi, Rui Yamaguchi, Hisashi Iwata, Fumiaki Watanabe, Trevor Clancy, Daisuke Muraoka, Shuichi Shinohara, Hiroyasu Komuro, Takuya Matsui, Yusuke Sugita, Ayako Demachi-Okamura, Katsuhiro Masago, Reina Nishida, Yoshiki Shigematsu, Katsutoshi Adachi, Hiroaki Kuroda, Yasunori Fukushima, Chieko Takashima, Takashi Ohki, Takashi Fukuyama, Daiki Miura, Kousuke Onoue, Kazuhide Onoguchi, Yoshiko Yamashita, Richard Stratford, Kiyoshi Doi
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e007180.full

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https://jitc.bmj.com/content/11/8/e007180.full

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