Development of N,N-Dimethylglycine-Amantadine for Adjunctive Dopaminergic Application: Synthesis, Structure and Biological Activity

Development of N,N-Dimethylglycine-Amantadine for Adjunctive Dopaminergic Application: Synthesis, Structure and Biological Activity

N-methyl-D-aspartate (NMDA) receptor blockade can improve L-DOPA (l-3,4-dihydroxyphenylalanine)-induced dyskinesias in Parkinson’s disease (PD) patients. Amantadine is a well-tolerated and effective antiparkinsonian agent, recently found to possess NMDA antagonistic properties. Oxidative damage may...

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Bibliographic Details
Main Authors: Radoslav Chayrov, Reni Kalfin, Maria Lazarova, Lyubka Tancheva, Hrisitna Sbirkova-Dimitrova, Boris Shivachev, Ivanka Stankova
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Crystals
Subjects:
amantadine
N,N-dimethylglycine
Parkinson disease
neuroprotective
dyskinesias
Online Access:https://www.mdpi.com/2073-4352/12/9/1227

Internet

https://www.mdpi.com/2073-4352/12/9/1227

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