Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells

Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Adrenocorticotropic Hormone Production and Tumorous Corticotroph Cell Growth in AtT20 Cells

Background: Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 (USP8) gene in pituitary corticotroph adenomas provide exciting advances in this field. These mutations drive increased epidermal growth factor receptor (EGFR) signaling and pr...

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Bibliographic Details
Main Authors: Fang-Fang Jian, Yun-Feng Li, Yu-Fan Chen, Hong Jiang, Xiao Chen, Li-Li Zheng, Yao Zhao, Wei-Qing Wang, Guang Ning, Liu-Guan Bian, Qing-Fang Sun
Format: Article
Language:English
Published: Wolters Kluwer 2016-01-01
Series:Chinese Medical Journal
Subjects:
Adrenocorticotropic Hormone Secretion; Cell Viability; Cushing's Disease; Ubiquitin-specific Protease 8 Inhibitor
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=17;spage=2102;epage=2108;aulast=Jian

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http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=17;spage=2102;epage=2108;aulast=Jian

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