CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

ABSTRACT Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved in the evasion of the murine IFNγ response have been identified, genes required to survive the human IFNγ response are larg...

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Bibliographic Details
Main Authors: Shruthi Krishnamurthy, Parag Maru, Yifan Wang, Mebratu A. Bitew, Debanjan Mukhopadhyay, Yoshiki Yamaryo-Botté, Tatiana C. Paredes-Santos, Lamba O. Sangaré, Christopher Swale, Cyrille Y. Botté, Jeroen P. J. Saeij
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
CRISPR screen
Toxoplasma gondii
effector functions
host-pathogen interactions
interferons
Online Access:https://journals.asm.org/doi/10.1128/mbio.00060-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00060-23

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