Gut Prevotellaceae-GABAergic septohippocampal pathway mediates spatial memory impairment in high-fat diet-fed ovariectomized mice

Gut Prevotellaceae-GABAergic septohippocampal pathway mediates spatial memory impairment in high-fat diet-fed ovariectomized mice

Clarifying the risk factors and mechanisms that contribute to the onset of cognitive impairment following estrogen depletion is essential for improving the quality of life of older females. In the current study, using behavioral tests, 16S rDNA sequencing, in vivo and in vitro electrophysiology, opt...

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Bibliographic Details
Main Authors: Shuai Zhang, Lu Zeng, Jing Ma, Wentao Xu, Yang Qu, Xuqiao Wang, Xiaobin An, Qin Wang, Yan Wu, Dongyang Wang, Haihui Chen, Jing Ai
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neurobiology of Disease
Subjects:
Gut microbiota
Estrogen deficiency
High-fat diet
Parvalbumin
Septohippocampal pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000074

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http://www.sciencedirect.com/science/article/pii/S0969996123000074

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