Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

Summary: A recurrent chromosomal translocation found in acute myeloid leukemia leads to an in-frame fusion of the transcription repressor ZMYND11 to MBTD1, a subunit of the NuA4/TIP60 histone acetyltransferase complex. To understand the abnormal molecular events that ZMYND11-MBTD1 expression can cre...

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Bibliographic Details
Main Authors: Maëva Devoucoux, Victoire Fort, Gabriel Khelifi, Joshua Xu, Nader Alerasool, Maxime Galloy, Nicholas Wong, Gaëlle Bourriquen, Amelie Fradet-Turcotte, Mikko Taipale, Kristin Hope, Samer M.I. Hussein, Jacques Côté
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
ZMYND11
MBTD1
NuA4
TIP60
AML
translocation
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200729X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472200729X

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