Antigen Presenting Cells from Tumor and Colon of Colorectal Cancer Patients Are Distinct in Activation and Functional Status, but Comparably Responsive to Activated T Cells

Antigen Presenting Cells from Tumor and Colon of Colorectal Cancer Patients Are Distinct in Activation and Functional Status, but Comparably Responsive to Activated T Cells

Although mouse models of CRC treatments have demonstrated robust immune activation, it remains unclear to what extent CRC patients’ APCs and TILs interact to fuel or quench treatment-induced immune responses. Our ex vivo characterization of tumor and adjacent colon cell suspensions suggest that cont...

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Bibliographic Details
Main Authors: Frank Liang, Azar Rezapour, Louis Szeponik, Samuel Alsén, Yvonne Wettergren, Elinor Bexe Lindskog, Marianne Quiding-Järbrink, Ulf Yrlid
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
colorectal cancer
tumor microenvironment
antigen presenting cells
T cells
Online Access:https://www.mdpi.com/2072-6694/13/20/5247

Internet

https://www.mdpi.com/2072-6694/13/20/5247

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