Advanced assessment through intact glycopeptide analysis of Infliximab’s biologics and biosimilar

Advanced assessment through intact glycopeptide analysis of Infliximab’s biologics and biosimilar

Characterization of therapeutic monoclonal antibodies (mAbs) represents a major challenge for analytical sciences due to their heterogeneity associated with post-translational modifications (PTMs). The protein glycosylation requires comprehensive identification, which could influence on the mAbs’ st...

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Bibliographic Details
Main Authors: Hyejin Kim, Geul Bang, Ye Eun Park, Moonhee Park, Jung Hoon Choi, Myung Jin Oh, Hyun Joo An, Jong Shin Yoo, Youngja Hwang Park, Jin Young Kim, Heeyoun Hwang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
monoclonal antibody
post-translational modification
ultra-high resolution mass spectrometry
infliximab
glycopeptide
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1006866/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1006866/full

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