Folding of matrix metalloproteinase-2 prevents endogenous generation of MHC class-I restricted epitope.

Folding of matrix metalloproteinase-2 prevents endogenous generation of MHC class-I restricted epitope.

BACKGROUND: We previously demonstrated that the matrix metalloproteinase-2 (MMP-2) contained an antigenic peptide recognized by a CD8 T cell clone in the HLA-A*0201 context. The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism. Surpris...

Полное описание

Библиографические подробности
Главные авторы: Virginie Renaud, Emmanuelle Godefroy, Pierre Larrieu, Fabrice Fleury, Francine Jotereau, Yannick Guilloux
Формат: Статья
Язык:English
Опубликовано: Public Library of Science (PLoS) 2010-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC2912773?pdf=render

Internet

http://europepmc.org/articles/PMC2912773?pdf=render

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