The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation

The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation

Excitotoxicity due to excessive activation of glutamate receptors is a primary mediator of cell death in acute and chronic neurological disorders, and NMDA-type glutamate receptors (NMDARs) are thought to be involved. NMDARs assemble from heteromeric combinations of GluN1, GluN2 and GluN3 subunits,...

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Bibliographic Details
Main Authors: Rebeca Martínez-Turrillas, Elena Puerta, Dhrubajyoti Chowdhury, Sonia Marco, Masahiko Watanabe, Norberto Aguirre, Isabel Pérez-Otaño
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
GluN3A
Neuroprotection
Calpain
Extrasynaptic NMDA receptors
3-nitropropionic acid
Huntington’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002422

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http://www.sciencedirect.com/science/article/pii/S0969996112002422

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