The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
Mutations in pendrin, a plasma membrane transporter, lead to Pendred syndrome, which is associated with hearing loss. Here, Jung et al. show that cell-surface expression of a mutated form of pendrin can be restored by blocking ER-to-Golgi traffic and triggering a DNAJC14 dependent unconventional sec...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11386 |