Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct

Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct

Sorting nexin 27 (SNX27), a PDZ (Postsynaptic density-95/Discs large/Zonula occludens 1) domain-containing protein, cooperates with a retromer complex, which regulates intracellular trafficking and the abundance of membrane proteins. Since the carboxyl terminus of aquaporin-2 (AQP2c) has a class I P...

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Bibliographic Details
Main Authors: Hyo-Jung Choi, Hyo-Ju Jang, Euijung Park, Stine Julie Tingskov, Rikke Nørregaard, Hyun Jun Jung, Tae-Hwan Kwon
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
aquaporin-2
lysosomal degradation
retromer complex
sorting nexin 27
Online Access:https://www.mdpi.com/2073-4409/9/5/1208

Internet

https://www.mdpi.com/2073-4409/9/5/1208

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