Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Abstract Background The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamide into NAD+, is the rate-limiting enzyme in the NAD+ salvage pathway...

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Bibliographic Details
Main Authors: Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen, Shu Zheng
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Cell Communication and Signaling
Subjects:
NAD+
NAMPT
FK866
Colorectal cancer tumors
Proliferation
Wnt/β-catenin
Online Access:https://doi.org/10.1186/s12964-020-0513-5

Internet

https://doi.org/10.1186/s12964-020-0513-5

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