Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains

Selective Inhibition of PDE4B Reduces Methamphetamine Reinforcement in Two C57BL/6 Substrains

Methamphetamine (MA) is a highly addictive psychostimulant drug, and the number of MA-related overdose deaths has reached epidemic proportions. Repeated MA exposure induces a robust and persistent neuroinflammatory response, and the evidence supports the potential utility of targeting neuroimmune fu...

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Bibliographic Details
Main Authors: Kevin M. Honeywell, Eliyana Van Doren, Karen K. Szumlinski
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
PDE4
methamphetamine
sex differences
reinforcement
addiction
C57BL/6substrains
Online Access:https://www.mdpi.com/1422-0067/23/9/4872

Internet

https://www.mdpi.com/1422-0067/23/9/4872

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