Identification of a novel Scn3b mutation in a Chinese Brugada syndrome pedigree: implications for Nav1.5 electrophysiological properties and intracellular distribution of Nav1.5 and Navβ3

Identification of a novel Scn3b mutation in a Chinese Brugada syndrome pedigree: implications for Nav1.5 electrophysiological properties and intracellular distribution of Nav1.5 and Navβ3

BackgroundThe Scn3b gene encodes for Navβ3, a pivotal regulatory subunit of the fast sodium channel in cardiomyocytes. However, its mutation status in the Chinese population suffering from Brugada Syndrome (BrS) has not been characterized, and the contributory pathophysiological mechanisms to diseas...

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Bibliographic Details
Main Authors: Jun Fan, Shao-hua Wang, Li-li Cao, Wei-jie Li, Shao-xi Sun, Shao-ling Luo, Yi-chao Pan, Wen-liang Tan, Tian-yuan Wu, Zhen Liu, Bing-bo Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Brugada syndrome (BrS)
Chinese
SCN3B
mutatation
sodium current
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1320687/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2024.1320687/full

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