Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.

Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.

Active-site serine D,D-transpeptidases belonging to the penicillin-binding protein family (PBPs) have been considered for a long time as essential for peptidoglycan cross-linking in all bacteria. However, bypass of the PBPs by an L,D-transpeptidase (Ldt(fm)) conveys high-level resistance to β-lactam...

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Bibliographic Details
Main Authors: Sébastien Triboulet, Vincent Dubée, Lauriane Lecoq, Catherine Bougault, Jean-Luc Mainardi, Louis B Rice, Mélanie Ethève-Quelquejeu, Laurent Gutmann, Arul Marie, Lionel Dubost, Jean-Emmanuel Hugonnet, Jean-Pierre Simorre, Michel Arthur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701632?pdf=render

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http://europepmc.org/articles/PMC3701632?pdf=render

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