Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

Mice deficient in the electron transport chain (ETC) complex IV assembly protein SURF1 have reduced assembly and activity of cytochrome c oxidase that is associated with an upregulation of components of the mitochondrial unfolded protein response (UPRMT) and increased mitochondrial number. We hypoth...

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Bibliographic Details
Main Authors: Gavin Pharaoh, Daniel Pulliam, Shauna Hill, Kavithalakshmi Sataranatarajan, Holly Van Remmen
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Stress resistance
Primary mouse fibroblasts
Paraquat (PQ)
Tert-butyl hydroperoxide (t-BuOOH)
Hydrogen peroxide (H2O2)
Mitochondrial unfolded protein response (UPRMT)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300301

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http://www.sciencedirect.com/science/article/pii/S2213231716300301

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