Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes

Testing the Pharmacokinetic Interactions of 24 Colonic Flavonoid Metabolites with Human Serum Albumin and Cytochrome P450 Enzymes

Flavonoids are abundant polyphenols in nature. They are extensively biotransformed in enterocytes and hepatocytes, where conjugated (methyl, sulfate, and glucuronide) metabolites are formed. However, bacterial microflora in the human intestines also metabolize flavonoids, resulting in the production...

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Bibliographic Details
Main Authors: Violetta Mohos, Eszter Fliszár-Nyúl, Beáta Lemli, Balázs Zoltán Zsidó, Csaba Hetényi, Přemysl Mladěnka, Pavel Horký, Milan Pour, Miklós Poór
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
polyphenols
colonic flavonoid metabolites
pharmacokinetic interaction
serum albumin
cyp450 enzymes
resorcinol
phloroglucinol
o-desmethylangolensin
Online Access:https://www.mdpi.com/2218-273X/10/3/409

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https://www.mdpi.com/2218-273X/10/3/409

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