USAGE OF MONOCLONAL ANTIBODIES FOR DETERMINATION OF LOCALIZATION OF ANTIGENIC DETERMINANTS AND FIBRIN POLYMERIZATION SITES WITHIN FIBRINOGEN AND FIBRIN MOLECULES AND THEIR APPLICATION IN TEST--SYSTEMS FOR DIAGNOSTICS AND THE THREAT OF THROMBUS FORMATION

USAGE OF MONOCLONAL ANTIBODIES FOR DETERMINATION OF LOCALIZATION OF ANTIGENIC DETERMINANTS AND FIBRIN POLYMERIZATION SITES WITHIN FIBRINOGEN AND FIBRIN MOLECULES AND THEIR APPLICATION IN TEST--SYSTEMS FOR DIAGNOSTICS AND THE THREAT OF THROMBUS FORMATION

It was shown by monoclonal antibodies that B?N-region of fibrin desA molecule (B?1-53) comprises the polymerization site including the peptide bond B?14-15. This site participates in the second stage of fibrin polymerization — lateral association of protofibrils. In the B?15-53 fragment was also fou...

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Bibliographic Details
Main Authors: E. V. Lugovskoi, I. N. Kolesnikova, S. V. Komisarenko
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2013-08-01
Series:Biotechnologia Acta
Subjects:
fibrinogen
fibrin
monoclonal antibodies
thrombosis
diagnostic test systems.
Online Access:http://biotechnology.kiev.ua/images/no4_2013/lugovskoy_4_2013.pdf

Internet

http://biotechnology.kiev.ua/images/no4_2013/lugovskoy_4_2013.pdf

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