Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?

Metformin and Cancer Glucose Metabolism: At the Bench or at the Bedside?

Several studies reported that metformin, the most widely used drug for type 2 diabetes, might affect cancer aggressiveness. The biguanide seems to directly impair cancer energy asset, with the consequent phosphorylation of AMP-activated protein kinase (AMPK) inhibiting cell proliferation and tumor g...

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Bibliographic Details
Main Authors: Cecilia Marini, Vanessa Cossu, Matteo Bauckneht, Francesco Lanfranchi, Stefano Raffa, Anna Maria Orengo, Silvia Ravera, Silvia Bruno, Gianmario Sambuceti
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
metformin
glucose consumption
FDG PET/CT imaging
endoplasmic reticulum
tumor metabolism
cancer therapy
Online Access:https://www.mdpi.com/2218-273X/11/8/1231

Internet

https://www.mdpi.com/2218-273X/11/8/1231

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