Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization

Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization

PurposeOsteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified.MethodsBased on the large individual-level datasets from UK Biobank as well as GWAS summary datasets, we first constructed genetic risk scores (GRSs) for 3...

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Bibliographic Details
Main Authors: Xing-Hao Yu, Rong-Rong Cao, Yi-Qun Yang, Lei Zhang, Shu-Feng Lei, Fei-Yan Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Public Health
Subjects:
metabolite
osteoporosis
bone mineral density
Mendelian randomization
genetic risk score
Online Access:https://www.frontiersin.org/articles/10.3389/fpubh.2022.905178/full

Internet

https://www.frontiersin.org/articles/10.3389/fpubh.2022.905178/full

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