Magnesium Isoglycyrrhizinate Attenuates Anti-Tuberculosis Drug-Induced Liver Injury by Enhancing Intestinal Barrier Function and Inhibiting the LPS/TLRs/NF-κB Signaling Pathway in Mice

Magnesium Isoglycyrrhizinate Attenuates Anti-Tuberculosis Drug-Induced Liver Injury by Enhancing Intestinal Barrier Function and Inhibiting the LPS/TLRs/NF-κB Signaling Pathway in Mice

Liver injury caused by first-line anti-tuberculosis (anti-TB) drugs accounts for a high proportion of drug-induced liver injury (DILI), and gut microbiota and intestinal barrier integrity have been shown to be involved in the development of DILI. Magnesium isoglycyrrhizinate (MgIG) is the fourth-gen...

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Bibliographic Details
Main Authors: Jin-Yu Gong, Huan Ren, Hui-Qing Chen, Kai Xing, Chen-Lin Xiao, Jian-Quan Luo
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
magnesium isoglycyrrhizinate
anti-tuberculosis drugs
liver injury
intestinal barrier
LPS/TLRs/NF-κB pathway
Online Access:https://www.mdpi.com/1424-8247/15/9/1130

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https://www.mdpi.com/1424-8247/15/9/1130

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