Methotrexate-Induced Liver Injury Is Associated with Oxidative Stress, Impaired Mitochondrial Respiration, and Endoplasmic Reticulum Stress In Vitro

Methotrexate-Induced Liver Injury Is Associated with Oxidative Stress, Impaired Mitochondrial Respiration, and Endoplasmic Reticulum Stress In Vitro

Low-dose methotrexate (MTX) is a standard therapy for rheumatoid arthritis due to its low cost and efficacy. Despite these benefits, MTX has been reported to cause chronic drug-induced liver injury, namely liver fibrosis. The hallmark of liver fibrosis is excessive scarring of liver tissue, triggere...

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Bibliographic Details
Main Authors: Saskia Schmidt, Catherine Jane Messner, Carine Gaiser, Carina Hämmerli, Laura Suter-Dick
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
methotrexate
liver fibrosis
in vitro model
HepaRG
oxidative stress
stellate cells
Online Access:https://www.mdpi.com/1422-0067/23/23/15116

Internet

https://www.mdpi.com/1422-0067/23/23/15116

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