Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids

Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids

Abstract Background Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in animal models of sepsis. Using a biotelemetry-enhanced, murine cecal ligation and puncture (CLP) model, we determined phenotyp...

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Bibliographic Details
Main Authors: Christopher W. Seymour, Samantha J. Kerti, Anthony J. Lewis, Jason Kennedy, Emily Brant, John E. Griepentrog, Xianghong Zhang, Derek C. Angus, Chung-Chou H. Chang, Matthew R. Rosengart
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Critical Care
Subjects:
Sepsis
Animal model
Antibiotics
Phenotype
Online Access:https://doi.org/10.1186/s13054-019-2655-7

Internet

https://doi.org/10.1186/s13054-019-2655-7

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