Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells

Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells

Abstract Background The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins in mammalian cell lines. However, these promoters are susceptible to si...

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Bibliographic Details
Main Authors: Roberto A Zúñiga, Matías Gutiérrez-González, Norberto Collazo, Pablo Hérnan Sotelo, Carolina H Ribeiro, Claudia Altamirano, Carmen Lorenzo, Juan Carlos Aguillón, María Carmen Molina
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Biological Engineering
Subjects:
Recombinant antibody production
Promoter
Gene expression
Chinese hamster ovary (CHO) cells
Online Access:http://link.springer.com/article/10.1186/s13036-019-0187-y

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http://link.springer.com/article/10.1186/s13036-019-0187-y

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