Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase

Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase

Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the...

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Bibliographic Details
Main Authors: Obi C. Umunakwe, Adam C. Seegmiller
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
fatty acid desaturase
linoleic acid
polyunsaturated fatty acid
adenosine 5′-monophosphate-activated protein kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352536

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http://www.sciencedirect.com/science/article/pii/S0022227520352536

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