Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling

Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling

Background: Ectopic activation of renin-angiotensin-system contributes to cardiovascular and renal diseases. (Pro)renin receptor (PRR) binds to renin and prorenin, participating in the progression of nephrology. However, whether PRR could be considered as a therapeutic target for cardiac remodeling...

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Bibliographic Details
Main Authors: Jing Zhang, Yun-Jiu Cheng, Chang-Jun Luo, Jia Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
(Pro)renin receptor
PRO20
heart failure
cardiac remodeling
endoplasmic reticulum stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.940365/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.940365/full

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