PRC1 suppresses a female gene regulatory network to ensure testicular differentiation

PRC1 suppresses a female gene regulatory network to ensure testicular differentiation

Abstract Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing female sexual differentiation remains unclear. Here,...

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Bibliographic Details
Main Authors: So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, Tony DeFalco, Satoshi H. Namekawa
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05996-6

Internet

https://doi.org/10.1038/s41419-023-05996-6

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