Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells

Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells

Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. Siglec-6 is an immunoreceptor tyrosine-based inhibitory motif...

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Bibliographic Details
Main Authors: Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
mast cell
Siglec-6
FcεRI
degranulation
ITIM
endocytosis
Online Access:https://www.mdpi.com/2073-4409/11/7/1138

Internet

https://www.mdpi.com/2073-4409/11/7/1138

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