Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes.

Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes.

Vaccinia Tian Tan (VTT) was attenuated by deletion of the TC7L-TK2L and TA35R genes to generate MVTT3. The mutant was generated by replacing the open reading frames by a gene encoding enhanced green fluorescent protein (EGFP) flanked by loxP sites. Viruses expressing EGFP were then screened for and...

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Main Authors: Shifu Kan, Yuhang Wang, Lili Sun, Peng Jia, Yanxin Qi, Jiaqiang Su, Lei Liu, Guohua Yang, Liming Liu, Zhuoyue Wang, Jinhui Wang, Guangchen Liu, Ningyi Jin, Xiao Li, Zhuang Ding
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3283712?pdf=render

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http://europepmc.org/articles/PMC3283712?pdf=render

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