Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development

Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development

Abstract Live-attenuated vaccines (LAVs) represent a promising approach for flavivirus vaccine development. In the present study, we demonstrated a method for generating flavivirus LAVs based on breaking spatially and temporally regulated C-prM cleavage to disturb the viral assembly process, using a...

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Bibliographic Details
Main Authors: Yu He, Jiaqi Guo, Xiaoli Wang, Senzhao Zhang, Li Mao, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng, Shun Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00468-y

Internet

https://doi.org/10.1038/s41541-022-00468-y

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