Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development
Abstract Live-attenuated vaccines (LAVs) represent a promising approach for flavivirus vaccine development. In the present study, we demonstrated a method for generating flavivirus LAVs based on breaking spatially and temporally regulated C-prM cleavage to disturb the viral assembly process, using a...
Main Authors: | Yu He, Jiaqi Guo, Xiaoli Wang, Senzhao Zhang, Li Mao, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Anchun Cheng, Shun Chen |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-022-00468-y |
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