Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In Vivo Characterization in Healthy Volunteers

Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In Vivo Characterization in Healthy Volunteers

The aim of the proposed study is to develop a mucoadhesive buccal delivery system for the sustained delivery of metformin (MET) and sitagliptin (SIT) against diabetes mellitus (DM) with improved bioavailability. Polymeric blend of Carbopol<sup>®</sup> 940 (CP), agarose (AG) or polyvinylp...

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Bibliographic Details
Main Authors: Rouheena Shakir, Sana Hanif, Ahmad Salawi, Rabia Arshad, Rai Muhammad Sarfraz, Muhammad Irfan, Syed Atif Raza, Kashif Barkat, Fahad Y. Sabei, Yosif Almoshari, Meshal Alshamrani, Muhammad Ali Syed
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
mucoadhesion
antidiabetic
volunteer study
Carbopol<sup>®</sup> 940
PVP
Online Access:https://www.mdpi.com/1424-8247/15/6/686

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https://www.mdpi.com/1424-8247/15/6/686

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