Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)

We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W, associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine metabolism and causes protein aggregation, autophagy and cell death in motor neuron cell lines. These features are consistent with th...

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Bibliographic Details
Main Authors: Nazanin R. Kondori, Praveen Paul, Jacqueline P. Robbins, Ke Liu, John C. W. Hildyard, Dominic J. Wells, Jacqueline S. de Belleroche
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
Amyotrophic lateral sclerosis
motor neurons
D-amino acid oxidase
survival study
motor phenotype
motor neuron degeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fmolb.2018.00008/full

Internet

http://journal.frontiersin.org/article/10.3389/fmolb.2018.00008/full

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